Restricted IgA Repertoire in Both B-1 and B-2 Cell-Derived Gut Plasmablasts

Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts.

Mucosal IgA is the most abundantly produced Ig upon colonization of the intestinal tract with commensal organisms in the majority of mammals. The repertoire of these IgA molecules is still largely unknown; a large amount of the mucosal IgA cannot be shown to react with the inducing microorganisms. Analysis of the repertoire of used H chain Ig (V(H)) genes by H-CDR3 spectrotyping, cloning, and s...

B cell repertoire in infants

© 2008 Weller et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 6 1331-1342 www.jem.org/cgi/doi/10.1084/jem.20071555 1331 In humans, peripheral blood B cells expressing the CD27 marker and mutated Ig receptors are usually considered to be memory B cells generated in germinal centers (GCs) during immune responses to T-dependent (TD) antigens. In adults, approximately half ...

Assessment of B Cell Repertoire in Humans.

The B cell receptor (BCR) repertoire is highly diverse. Repertoire diversity is achieved centrally by somatic recombination of immunoglobulin (Ig) genes and peripherally by somatic hypermutation and Ig heavy chain class-switching. Throughout these processes, there is selection for functional gene rearrangements, selection against gene combinations resulting in self-reactive BCRs, and selection ...

B cell repertoire diversity in athymic mice

The extent of B cell repertoire diversity among nu/nu BALB/c mice has been assessed and compared with that of normal BALB/c mice. This was accomplished through the characterization of monoclonal, influenza hemagglutinin-specific antibodies by reactivity pattern analysis. The results indicate that the repertoire of athymic mice is equivalent in diversity to that of normal mice. Moreover, because...

T Cell Repertoire − Compartments of the CD 1 b TCR